Process Record Slide (PRS)
a Must-Have Diagnostic Tool for Pathologist  
Process Record Slide (PRS) Technology
Currently, there is a gap in Pathology laboratory quality and process control for stained microscope slides. Process Record Slide (PRS) was specifically created to fill that gap. It provides co-resident patient samples with control targets which experience the staining process together. The stained controls immediately show any process errors as deviations against a known target baseline. PRS has been FDA registered as Class I as the first and only slide by slide calibrator.
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Speakers Of Our Webinar
Frederick K. Husher
Chief of R&D
Mr. Husher has more than 40 years experience in R&D, product development and business development. Mr. Husher has worked for Tektronix, University of New Mexico, Megiddo, US Military Joint Services, Amtech, Gtech, Beckman Coulter, Veracel, Barfield EADS, JAF Development Corp, and Crane Cams in various Electrical Engineering and Management positions.
Jee J. Shum
Chief of R&D
Mr. Shum has more than 40 years experience in product manufacturing, which has included stadium class light message boards, computers, pick & place assembly robotics, and laser engraving. Mr. Shum has owned and managed a number of successful companies both in the USA and foreign counteries, with the most recent being American PC. Additionally, Mr. Shum is experienced in negotiating and managing manufacturing in China.
From selective / batch control to 100% Quality Control
Presently, all clinical laboratory QC is limited to batch controls. PRS delivers 100% QC at a cost-effective price with easy acceptance threshold criteria. The full QC eliminates false negative reporting caused by staining process defects. Using the PRS control targets, the digital imaged results now have an antigen measurement scale that enables quantifiable decisions to be made. Thus, second opinion and tele-diagnostics have the basis to reach diagnostic decision consensus.
PRS moves the standard of care for all clinical laboratories
ISO 15189 mandates that any tool that improves quality of patient care otherwise unattainable MUST be adopted.
PRS meets this criteria by providing 100% QC and a measurement scale of antigen concentration on the patient sample. The 100% QC ensures that the slides were processed within the processing protocol limits, greatly reducing defective slides. Assuming the tissue sample was fixed correctly, the interpreting pathologist can reach a valid diagnostic result.

Realizing the potential of digital diagnostics

Digital solutions promise so much, but have failed to deliver because the patient slides lack a processing record. The lack of the processing record causes artificial intelligence (AI) programs to guess when comparing against their databases. Worse yet, is that the defectively processed slide causes the database to be corrupted with whatever decision is made. With the PRS, slides now contain the processing record which supports quantitative measurement and ensures the database becomes more capable in diagnostic support.
Process Record Slide
Why do you choose Process Record Slide?
A significant advantage of the PRS architecture is the  ability to extrapolate a
primary density ruler from a secondary gradient array.
  •  Improve patient care
  •  Promote staff satisfaction
  •  Streamline operational efficiency
  •  Strengthen financial health
Features and Uses
Process Record Slide is an innovative solution that adds quality control monitoring for the patient tissue section on each glass slide. It also serves as a slide by slide calibrator
  •  IHC Staining - Get an effective record of the IHC staining experience
  •  Quality Control Evaluation - Target data provides objective QC evaluation of the processing experience
  •  Concentration Ruler - Target data forms the basis of an antigen concentration ruler
  •  Pre-Screening - The ruler provides a digital imaging baseline for pre-screening
  •  Imaging Adjustment - The ruler supports imaging adjustment so the viewing Pathologist can make the best diagnostic interpretation
  •  2nd Opinion and Remote Diagnostic Opportunity - 2nd opinion is possible when the observer can see the processing record and know what was done to the PRS and tissue section
Process Record Slide Products
Why PRS?
Our product, the Process Record Slide (PRS) came about due to a book published by the World Health Organization (WHO). If you Google “Laboratory Quality Control”, you will find a copy of a book entitled “Laboratory Quality Control System” . This book provides details of the universal quality control rules for health related laboratories.
How does PRS help laboratories?
We strongly recommend that all laboratories consider using PRS for their IHC biopsy staining process particularly in view of the fact that WHO states this quality control component is an essential element. By including this, the laboratory can confirm the efficacy of reagents used, tissue handling, and process control of the patient sample through the IHC processing. Thus, the laboratory can document that its processing of the biopsy sample is valid prior to the diagnostic interpretation being performed. Of course, the biopsy may not contain any of the sought for conditions and the outcome would be a true negative result.
WHO also goes on to stress that if QC is missed from the process, then laboratories should not consider reporting the patient results at all:
If QC results are not what are expected, do not report patient results.
If you are a laboratory that wishes to comply with the WHO guidelines, then the Process Record Slide (PRS) product is for you. Contact us now for full details and get your laboratory fully QC compliant and your patient reports fully controlled and recorded.
How does PRS help physicians?
The Process Record Slide (PRS) contains an array of immunohistochemical (IHC) reactive targets that are co-resident with an applied patient tissue section. Both the target array and patient tissue section go through the full IHC processing experience together. The target array's reactivity to one or more of the staining reagents records the cumulative experience of the co-resident tissue section. Human origin materials are not used as part of the target arrays. Thus, each PRS contains its own unique IHC processing experience record for the co-resident tissue section. Slide-to-slide analysis of the PRS array data can be used in quality control of the IHC process using statistical variance tracking. The PRS target array provides digital imaging with calibrating targets that uniquely express the staining experience of the co-resident tissue section.

With our PRS, you will be able to:
  •  Provide a record of the processing experience of the target and the tissue section experienced. The target data can be used to verify that the processing and reagents are functioning within their tolerance limits as defined in the laboratory’s process control documents.
  •  Record the IHC staining experience and identify process or reagent deficiencies that may occur.
  •   Change the subjective diagnostic interpretation into objective interpretation because the efficacy of the IHC processing is known to be valid via the PRS target results.
  •  Validate and support corroborative 2nd opinion and tele-diagnosis within even remote communities across the globe.
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